Motor Neuron Diseases
Motor neuron diseases are neurological diseases that destroy neurons. They are progressive diseases that occur in adults and in children. In general, motor neuron diseases are a group of progressive neurological disorders that destroy motor neurons, which are cells that control essential voluntary muscle activity such as speaking, walking, breathing, and swallowing.
The treatment of motor neuron diseases with stem cells is an important treatment in the medical field. The relevant introduction is as follows:
Therapeutic Principles
• Cell Replacement Effect: Stem cells can differentiate into motor neuron cells, replenishing the motor neurons that have died or been damaged due to the disease, and restoring nerve conduction function. For example, in animal experiments, transplanted neural stem cells can differentiate into functional motor neurons in specific areas and establish connections with the surrounding nerve tissues.
• Secretion of Neurotrophic Factors: Stem cells can secrete a variety of neurotrophic factors, such as brain-derived neurotrophic factor and nerve growth factor. These factors support and protect motor neurons, promote their survival and regeneration, improve the microenvironment of nerve cells, and enhance cell activity and function.
• Immunomodulatory Effect: There are immune abnormalities in motor neuron diseases. Stem cells can regulate the immune system, inhibit the inflammatory response, reduce the damage of immune cells to nerve cells, and decrease the toxic effects of inflammatory factors on motor neurons, creating a favorable environment for recovery.
Stem Cell Transplantation Routes:
Mainly including intravenous infusion, intrathecal injection, and local injection. Intravenous infusion is simple to operate and has minimal trauma, but stem cells may be trapped in organs such as the lungs. Intrathecal injection can make the stem cells closer to the lesion site, but it has certain operational risks. Local injection can precisely deliver stem cells to the damaged area, but it requires high technical skills and is suitable for lesions in specific locations.
Cases
