Traumatic Brain Injury (TBI)
Traumatic brain injury (TBI) is brain tissue damage caused by external mechanical forces, leading to temporary or permanent neurological dysfunction. Common causes include traffic accidents, falls from heights, and violent impacts. The pathological mechanisms involve both primary injury and secondary injury, such as cerebral edema, increased intracranial pressure, ischemia-hypoxia, and neuroinflammation. The most commonly affected areas are the frontal and temporal lobes, with clinical manifestations including consciousness impairment, cognitive deficits, motor coordination abnormalities, speech disorders, and emotional and behavioral changes. Given the brain’s limited regenerative capacity, severe TBI often results in the loss of self-care ability, regression in social roles, and long-term complications such as epilepsy and autonomic dysfunction.
Stem cell therapy for TBI is an innovative strategy based on neural regeneration and modulation of the injury microenvironment. It aims to repair damaged neural networks, inhibit the progression of secondary injury, and achieve functional compensation and structural reconstruction. The therapeutic mechanisms and clinical benefits are outlined below::
- Brain-derived neurotrophic factor (BDNF)
- Nerve growth factor (NGF)
- Neurotrophin-3 (NT-3)
UC-MSCs secrete vascular endothelial growth factor (VEGF), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM- 1). These factors directly or indirectly contribute to neurovascular formation and injury repair, ensuring adequate blood supply to damaged brain tissue.
Since completing the first stem cell therapy case for a patient with traumatic brain injury (TBI) in 2004, we have established ourselves as one of the earliest institutions in China to apply stem cell therapy in this domain. Over the years, we have amassed extensive clinical experience, enabling us to conduct comprehensive assessments of each patient’s condition and to formulate timely, accurate, and individualized treatment strategies.
Our treatment protocols incorporate a wide range of cell delivery methods, including intravenous infusion, stereotactic cranial transplantation, lumbar puncture, acupoint injection, and intranasal administration. Based on the patient's specific clinical profile, we employ an integrated, evidence-based approach to ensure precise targeting of the lesion site and to significantly enhance therapeutic efficacy.
Beyond treating central nervous system dysfunction resulting from TBI, we actively address associated complications such as cranial defects and myositis ossificans. Our integrated approach has yielded consistently positive outcomes, offering robust support for holistic patient rehabilitation.
Our accomplishments in stem cell therapy for TBI have attracted widespread media attention, and our clinical data have been compiled into published professional literature. These milestones underscore our significant technical expertise and leadership within the field.
We uphold a multidisciplinary treatment philosophy that brings together the strengths of various medical disciplines to develop comprehensive, systematic care plans. In addition, we implement long-term follow-up mechanisms to monitor patient progress and adapt treatment protocols as needed—ensuring sustained, personalized support throughout the recovery journey.
Since 2004, Our medical team has successfully performed over 1,800 cases of stem cell therapy for TBI, achieving an overall efficacy rate of 85.2%. Our treatment covers a wide range of injury types:
Includes cerebral contusions and subdural hematomas, often accompanied by localized neurological deficits.
Widespread damage to white matter fibers, leading to consciousness impairment and cognitive decline.
High risk of infection, requiring a combination of anti-inflammatory and neuroregenerative treatments.
Severe cases characterized by autonomic instability and long tract signs.
Key Improvements Noted in Patients:
In the treatment of traumatic brain injury (TBI) , we integrate stem cell technology, neuromodulation, and AI-assisted rehabilitation training to offer diverse therapeutic options within a comprehensive service system. Our approach extends beyond the restoration of physical function—we place equal emphasis on psychological rehabilitation and family empowerment, supporting patients in reclaiming their dignity and sense of purpose.
